This one-day symposium provides a comprehensive update on the long-term issues faced by adult Fontan survivors. The course focuses on patients with “failing” Fontan physiology and the available tools and therapies for the treatment of this challenging subset of patients, including updates on medical therapies, catheter-based and surgical techniques for palliation and support. The ultimate therapeutic options of orthotopic heart and multi-organ transplantation are covered in detail as the need grows in this aging Fontan population. The target audience includes adult and pediatric congenital cardiologists, congenital and transplant cardiac surgeons, heart failure/transplant specialists, hepatologists, liver transplant surgeons, cardiac intensivists, cardiology and cardiac surgery trainees, cardiac nurses, nurse practitioners and physician assistants.